Adam john hughes
Regulation of sterol synthesis in eukaryotes. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion. Warren CD, Eckley DM, Lee MS, Hanna JS, Hughes A, Peyser B, Jie C, Irizarry R, and Spencer FA (2004).SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Hughes AL, Todd BL, Espenshade PJ (2005).Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ (2006).Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ (2007).Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, Chang YC (2007).4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. Hughes AL, Lee CY, Bien CM, Espenshade PJ (2007).Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP. Hughes AL, Stewart EV, Espenshade PJ (2008).Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ (2008).An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast. Henderson KA, Hughes AL, Gottschling DE (2014).Power(2): the power of yeast genetics applied to the powerhouse of the cell.
Selective sorting and destruction of mitochondrial membrane proteins in aged yeast. Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE (2016).Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact.